The artist has donated the full amount of his £25k Mercury Prize winnings to the MVT, which operates to protect the UK's independent live music spots.
Fender was awarded the award on 16 October as his third album People Watching was named the best record of the last 12 months.
Fender has opted to give the cash to the Music Venues Trust, in recognition of the essential function small stages played in his early career.
"I personally would not have achieved this success if it hadn't been for all the performances I played around the North East, and beyond, when I was just getting going," remarked the artist. "These locations are renowned, but they are facing challenges."
Beginning in 2023, over 150 of these spaces have ceased operations – approximately 16% of the whole industry in the UK.
Recently, top acts including the band Pulp, Coldplay, the singer Katy Perry and Ed Sheeran have all backed the Music Venues Trust in its attempts to help venues survive, by applying a modest fee to their ticket costs, which goes to help local stages.
Sam Fender also took part, collecting more than £100,000 on his 2024 arena tour to help numerous small stages across the UK.
The money supported venues that were confronting possible closure due to issues arising from floods, fires and bereavements, as well as licensing issues, court cases and noise complaints.
Other venues were granted monetary aid in improving infrastructure and gear that directly benefitted performers and audiences.
"The notion that money from performances in major spaces helps the local stages, where it kicks off for musicians like me, is just sensible," Sam Fender has said.
Fender is far from the only musician to donate his Mercury Prize funds to charitable organizations.
When Pulp earned the trophy in the mid-90s for their record the album, lead singer the singer announced that the band would donate their winnings to the organization the charity.
In 2002, artist she divided her prize among multiple organizations, like the NSPCC and a Sickle Cell charity.
"And I contributed a grand to the center, to their classes, because I trained in gymnastics when I was a child and they required new equipment," the artist explained to outlets.
Two years ago, the band gave their prize money to the community center that developed their band, in addition to other grassroots music organisations.
Also winners that year they contributed their award to a multiple sclerosis charity after a acquaintance was found to have the illness.
"Winning was quite enough," remarked singer Heather Small. "The cash was the bonus but we didn't require the extra, because we had the cake. So our success affected somebody else's life."
In the past week, the MVT announced it had protected several small stages in the South East, by transferring them to public stewardship.
The Joiners in that area and the second in the city were purchased under the public acquisition program, which is funded by Arts Council England and supporters who acquire "stakes" in the properties.
