The Monarch has filmed a first-hand account about his journey with cancer, scheduled for transmission as part of this year's Stand Up To Cancer initiative, run by Cancer Research UK and Channel 4.
The royal household said the King would reflect on his "recovery journey" as a cancer patient, in a recorded address on Friday at 8pm UK time.
The recording, recorded at a royal residence two weeks ago, will highlight the importance of cancer screening checks to help guarantee more people catch the condition at an initial point.
This will be a infrequent public commentary on the health of the King, who has been receiving ongoing care since the news was shared in the start of 2024. But it is thought improbable the King will specify his type of cancer.
The annual charity campaign each year generates donations for clinical trials and patient care and encourages people to get screenings to improve the chances of an timely detection.
The King's candid approach about his condition, and managing the disease, has been aimed to promote education and to encourage more people to get screened - and this will be advanced with this unusual direct participation.
So far the King's primary strategy to his cancer has been to continue his schedule, upholding a hectic timetable in spite of his regular rounds of treatment, and he seems not to have desired to be overshadowed by his illness.
This year has seen the King, 77, taking several overseas trips, such as visits to Italy and Canada, and welcoming the biggest number of foreign dignitaries to the UK for almost 40 years, including the German president in recent days.
The upcoming awareness show on television, featuring celebrities including a team of famous hosts, will appeal to people not to be frightened of getting preventative tests.
All three have been affected by cancer - McCall said last month she had received treatment for the disease, while Balding was diagnosed with thyroid cancer more than 15 years ago. Host Adam Hills has previously spoken about his late father, who had a diagnosis and then later leukaemia.
The programme will appeal to the approximate nine million people in the UK who charities state are not current with public health checks, with an website to let people determine if they are eligible for screenings for breast, bowel and cervical cancer.
In an attempt to clarify cancer checks and illustrate the value of prompt detection there will be a real-time transmission from treatment centres at medical facilities in Cambridge.
"My aim is to reduce the stigma out of cancer screening and demonstrate everyone that they are not isolated in this," commented a presenter.
Currently in the UK, there are three NHS cancer screening programmes - for specific cancers - offered to certain age groups.
A recently launched preventative initiative is also being gradually implemented for people at potential risk of being diagnosed with the condition, primarily aimed at people of a certain age, who currently smoke or have smoked in the past.
Male patients may request specific tests, but there is lacking a standardised service currently available.
The Stand Up to Cancer campaign, which has raised a significant sum for many years, is supporting 73 research studies encompassing many patients.
The Monarch, in a statement for attendees at a event for support groups in the spring, had spoken of acknowledging the "overwhelming and at times frightening situation" for those diagnosed and their families.
But he said his experience of living with cancer had revealed that "the most difficult times of sickness can be alleviated by the kindness of others," as he thanked those who looked after those receiving treatment.
Royal representatives has not disclosed the specific type of cancer the King has, or the therapies he has received. The King's cancer was identified following he had undergone a routine operation.